Bile duct cancer is called cholangiocarcinoma. It arises from the epithelium or biliary tree lining either within the liver or in ducts located outside of the liver. Cholangiocarcinoma is difficult to cure and many cases are sporadic with no identifiable etiology or cause.
Risk factors associated with cholangiocarcinoma include: Primary sclerosing cholangitis (PSC), Ulcerative colitis , Liver fluke infestations, Chronic cholestasis with chronic stone disease, Congenital biliary cystic anomalies